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It was originally developed as a safer alternative to hGH for metabolic applications, and it is now one of the most used peptides for weight loss in supervised clinical settings
Wegovy European Public Assessment Report (EPAR)
Tresiba has no role in weight management
Absolute contraindications to GLP-1 receptor agonists include: Personal history of medullary thyroid carcinoma Family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Pregnancy (for weight management indications) Severe gastrointestinal disease, including gastroparesis Patients should be specifically questioned about these conditions during pre-treatment evaluation
Interestingly, the obese MCAS patients tolerated the high dose quite well, while others did fine on lower doses
FREQUENTLY ASKED QUESTIONS No definitive evidence links GLP-1 medications to direct hair loss
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